2-Bromo-6-fluorobenzaldehyde

2-Bromo-6-fluorobenzaldehyde is a halogenated aromatic aldehyde with two independent synthetic handles. The formyl group supports condensation, reduction and reductive amination, while the aryl bromide enables carbon–carbon coupling. The retained fluorine and the two substituents flanking the aldehyde define the position and steric environment of the fragment introduced into downstream molecules.

The selected material is the aldehyde, rather than the corresponding benzyl alcohol or benzoic acid. Its carbonyl can be converted into an amine-bearing side chain without first constructing the aromatic framework, or the bromine can be transformed while the formyl group is protected. This permits different sequences for assembling fluorinated aromatic intermediates and differentiates it from bromo-fluorobenzaldehydes with other substitution patterns.

Typical Applications

• Fluorinated benzylamine synthesis: Used in reductive amination with suitable amines to introduce a nitrogen-containing side chain at the formyl position, retaining the aromatic substitution pattern for downstream chemistry.
• Biaryl aldehyde intermediates: Used in aryl-bromide coupling sequences to extend the aromatic framework while retaining or temporarily protecting the aldehyde for a subsequent carbonyl transformation.

Specifications

Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.