Custom Synthesis
From a structure and a specification to a reproducible route — including the scale-up steps most catalogues skip.
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- 定制项目汇总
- 可公开案例
- 常做反应类型
What We Take On
Projects start from a structure, an impurity profile or an existing route that no longer works at scale.
01
Route scouting
Literature and internal know-how combined into 2-3 candidate routes, compared on yield, cost and safety.
02
Process optimisation
Solvent, stoichiometry and work-up optimised for reproducibility rather than single-lab yield.
03
Scale-up
Lab → pilot → commercial, with in-process controls defined at each step. Pilot scale is matched to the commercial reactor train.
04
Impurity work
Impurity identification, synthesis of markers and specification setting for the customer’s method.
How a Project Runs
Each stage ends with a written deliverable, so you can stop the project between stages without losing the work.
01
NDA & brief
Structure, specification, quantity, target date and any regulatory constraints.
02
Feasibility report
Route options, risks, estimated cost and timeline.
03
Lab sample
10-100 g under the proposed specification, with analytical data.
04
Scale-up & supply
Pilot then commercial batches, CoA per lot.
Working Under NDA
Structures and project data are handled on a need-to-know basis; we sign the customer’s NDA or provide ours, whichever your legal team prefers.
Project files are stored separately from catalogue product data, and only the project team has access. Analytical data and batch records are retained so the route can be reproduced years later.
We sign your NDA or provide ours — whichever your legal team prefers.
What Happens at Each Stage
A custom project is a sequence of decisions. Each stage ends with something you can read and approve.
| Stage | What we deliver | What we need from you |
|---|---|---|
| Scoping | A written assessment of feasibility and cost | Structure or CAS, purity, quantity, timeline |
| Route scouting | Candidate routes with the key risks named | Known constraints: IP, starting materials, equipment |
| Lab sample | A sample with an analytical sheet | Acceptance criteria and your method |
| Scale-up | A repeatable process description and a pilot batch | Target batch size and packaging |
| Validation | Three consecutive batches with full documentation | The specification the batches must meet |
Nothing is scaled before the previous stage is signed off.
What We Need to Quote a Project
Most delays at quotation stage come from missing one of these four answers.
01
What you are making
The structure or CAS, and what the material is used for.
02
What purity means to you
Assay, impurity limits, or a method you already use.
03
How much and how fast
The first quantity, the annual need, and the date.
04
What constrains you
IP position, forbidden solvents, packaging, target market.
Send a structure and a target specification
We reply with a feasibility view first — whether the route is realistic, and what it would take.