6-Amino-1-methyluracil
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Molecular formula
Molecular weight
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Chemical Product Description & Applications
6-Amino-1-methyluracil is an amino-substituted pyrimidinedione used to construct more complex nitrogen heterocycles. Its exocyclic amino group and adjacent ring position participate in condensation and annulation chemistry, while the two carbonyls provide a preformed uracil-like framework. The N-methyl substituent fixes one nitrogen substitution pattern before ring expansion or fusion.
The selected material is the amino compound, not 6-chloro-3-methyluracil. Its amino-enone-like reactive arrangement permits carbonyl partners to be incorporated into fused or spiro heterocyclic products. The pyrimidinedione carbonyls also contribute hydrogen-bonding sites in molecular-recognition studies. These functions support chemical synthesis and supramolecular investigation without requiring the material to be assigned an unverified commercial pharmaceutical indication.
Typical Applications
- Fused and spiro heterocycle synthesis: Used in condensation sequences with carbonyl partners, including reported isatin reactions, to construct more complex pyrimidine-containing fused or spiro ring systems.
- Host–guest molecular-recognition studies: Used as a carbonyl- and amino-bearing guest in investigations of hydrogen-bonding and association with macrocyclic hosts, including reported calixarene systems.
Specifications
| Parameter | Specification | Test Method |
|---|---|---|
| Appearance | Solid; color consistent with the reference sample | Visual inspection |
| Identification | Consistent with authenticated reference | FTIR fingerprint comparison |
| Chromatographic purity | ≥98.0 area% | HPLC with suitable UV or CAD detection |
| Total organic impurities | ≤2.0 area% | HPLC, area normalization |
| Largest individual impurity | ≤1.0 area% | HPLC, area normalization |
| Water | ≤1.0% w/w | Karl Fischer titration |
Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.
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