2-[1-(Ethylsulfonyl)azetidin-3-ylidene]acetonitrile

2-[1-(Ethylsulfonyl)azetidin-3-ylidene]acetonitrile is an activated alkene intermediate used in baricitinib synthesis. The nitrile-substituted double bond provides a conjugate-addition site, while the N-ethylsulfonyl azetidine transfers the required four-membered-ring fragment. The nitrile is retained as part of the side-chain framework after alkene conversion.

The selected compound is the unsaturated intermediate rather than a saturated azetidine acetonitrile or the completed kinase inhibitor. Its ring nitrogen is already sulfonylated, so downstream chemistry can focus on addition to the exocyclic alkene. This preassembled arrangement connects the nitrogen-protection/substitution stage with fragment coupling, making the material specific to routes requiring the ethylsulfonyl azetidine and nitrile pattern together.

Typical Applications

• Baricitinib side-chain coupling: Used as the activated alkene partner in addition chemistry that installs the N-ethylsulfonylazetidine–acetonitrile fragment into the developing heterocyclic framework.
• Azetidine-containing pyrazole analogues: Used in reported analogue synthesis as an unsaturated nitrile building block, generating related side-chain structures while preserving the sulfonylated azetidine ring.

Specifications

Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.