2-Fluoro-5-formylbenzoic acid

2-Fluoro-5-formylbenzoic acid is a fluorinated aromatic intermediate containing a formyl group and a free carboxylic acid. The aldehyde supplies a site for carbon–carbon bond formation, while the acid permits amide coupling or temporary ester protection. This combination is useful for assembling substituted benzyl and benzoyl fragments in phthalazinone-oriented synthesis.

The fluorine occupies the position adjacent to the acid, fixing the substitution pattern retained in downstream products. The two carbonyl-containing groups can be transformed at different stages: aldehyde elaboration extends the aromatic framework, and acid activation connects it to an amine. The selected free acid offers this coupling function directly, distinguishing it from the corresponding nitrile or protected ester.

Typical Applications

• Olaparib-related aromatic intermediates: Used in routes that elaborate the aldehyde into the benzyl-linked phthalazinone framework while preserving the fluorobenzoic-acid fragment for subsequent amide construction.
• Formyl-substituted benzamides: Used as the acid component in coupling with protected amines, producing benzamides that retain an aldehyde handle for further condensation or fragment assembly.

Specifications

Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.