N-Ethyl-2-(4-formylphenyl)acetamide
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Molecular formula
Molecular weight
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Chemical Product Description & Applications
N-Ethyl-2-(4-formylphenyl)acetamide is an aromatic aldehyde carrying a preinstalled N-ethylacetamide side chain. The formyl group supports formation of a benzyl–nitrogen linkage, while the amide supplies a precursor to an N-ethylaminoethyl substituent after carbonyl reduction. These two functions allow different portions of an aminoethyl-substituted aromatic fragment to be developed in stages.
The selected material retains the amide carbonyl, distinguishing it from the corresponding aminoethyl benzaldehyde. Its aldehyde can connect the aromatic ring to a complementary amine before the side-chain oxidation state is changed. Protection or prior conversion of the aldehyde separates its chemistry from amide reduction. This makes the intermediate relevant to routes in which benzyl attachment and terminal amine preparation occur at different points.
Typical Applications
- Benzylamine-linkage construction: Used as the aldehyde partner in reductive-amination chemistry, connecting the para-substituted aromatic fragment to a complementary amino-containing core.
- N-Ethylaminoethyl fragment preparation: Used in routes that reduce the side-chain amide after suitable management of the aldehyde, generating the aminoethyl unit needed for later or completed side-chain assembly.
Specifications
| Parameter | Specification | Test Method |
|---|---|---|
| Appearance | Solid; color consistent with the reference sample | Visual inspection |
| Identification | Consistent with authenticated reference | FTIR fingerprint comparison |
| Chromatographic purity | ≥98.0 area% | HPLC with suitable UV or CAD detection |
| Total organic impurities | ≤2.0 area% | HPLC, area normalization |
| Largest individual impurity | ≤1.0 area% | HPLC, area normalization |
| Water | ≤1.0% w/w | Karl Fischer titration |
Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.
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