(S)-5-(2,2-Dimethyltetrahydro-2H-pyran-4-yl)-N-methyl-N-phenyl-1H-indole-2-carboxamide

This chiral tetrahydropyranyl indole carboxamide is an intermediate in orforglipron-related synthesis. Its free indole NH enables introduction of a nitrogen-linked side chain, while the N-methyl-N-phenyl carboxamide carries the carboxyl-derived functionality through early operations. The S-configured tetrahydropyran group is already attached at the indole ring.

The selected compound precedes installation of the substituted cyclopropyl group on indole nitrogen. N-Alkylation creates a nitrile-bearing side chain that can be elaborated into the later cyclopropyl and oxadiazolone functions. At a subsequent stage, conversion of the carboxamide exposes the indole acid used for advanced-fragment coupling. This divides side-chain construction from release of the final acyl-coupling handle.

Typical Applications

• Indole N-Cyanomethyl intermediates: Used in N-alkylation to attach a cyanomethyl group, establishing the starting side chain for later methylcyclopropyl-fragment construction.
• Advanced indole-acid preparation: Used in multistep routes that elaborate the indole nitrogen substituent and subsequently convert the carboxamide into the acid required for final fragment coupling.

Specifications

Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.