(S)-3-[1-(Dimethylamino)ethyl]phenol

(S)-3-[1-(Dimethylamino)ethyl]phenol is a chiral phenolic precursor to rivastigmine and corresponds to its decarbamylated structural fragment. It provides the required S-configured aminoethyl side chain and a phenolic hydroxyl that can be converted into the ethylmethylcarbamate group. These features make it relevant both to synthetic assembly and to analysis of rivastigmine-related material.

The selected form is the free compound, not the hydrochloride and not the R enantiomer. Its unprotected phenol allows direct access to oxygen functionalization, while the tertiary amine remains part of the final molecular skeleton. The same identity is associated with rivastigmine-related compound analysis, but a synthesis-grade lot should not be described as a certified analytical standard without the appropriate characterization.

Typical Applications

• Rivastigmine synthesis: Used as the S-configured phenol in carbamoylation routes that construct the drug’s aryl carbamate, retaining the existing dimethylaminoethyl stereocenter.
• Related-compound analytical studies: Used as an identified decarbamylated comparator during development of chromatographic methods for rivastigmine, helping distinguish the phenolic precursor from the intact carbamate.

Specifications

Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.