D-Penicillamine

D-Penicillamine is a stereodefined thiol-containing amino acid with metal-chelating and disulfide-exchange functions. Its sulfur-containing structure binds copper and other metals, while thiol–disulfide exchange underlies its interaction with cystine. These distinct chemical actions account for its established pharmaceutical relevance in copper-overload disorders and cystinuria.

The D form is different from L-penicillamine and the DL racemate. It contains amino, carboxyl and hindered thiol groups, allowing both coordination and covalent sulfur chemistry. This material is relevant to drug-substance development, dosage-form research and mechanistic investigation. Reference to medicinal applications describes the molecule’s established role and does not imply that an unspecified commercial lot already meets pharmaceutical release requirements.

Typical Applications

• Oral penicillamine dosage-form development: Used as the active compound in development of oral formulations associated with copper-chelation therapy, including work on compatibility, release and stability of the thiol-containing drug.
• Copper-binding research: Used in coordination and biological model systems to investigate copper complexation, linking thiol-containing ligand structure with metal-binding behavior.
• Cystine disulfide-exchange studies: Used to examine formation of penicillamine–cysteine mixed disulfides, the chemical process relevant to reducing poorly soluble cystine in cystinuria research.

Specifications

Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.