(S)-3-Aminoquinuclidine dihydrochloride

(S)-3-Aminoquinuclidine dihydrochloride is a chiral bicyclic diamine salt used in pharmaceutical synthesis. Its primary amino group supports amide or urea formation, while the rigid quinuclidine framework introduces a defined basic nitrogen-containing three-dimensional fragment. The S-configured center fixes the orientation of the exocyclic amino substituent before downstream coupling.

Both the primary amine and the bridgehead tertiary amine are represented in the dihydrochloride salt. Releasing the reactive primary amine permits selective connection to a carboxylic-acid-derived fragment while the bridgehead nitrogen remains part of the bicyclic skeleton. The selected material is therefore a chiral fragment precursor rather than a finished antiemetic, and its S configuration must be retained when assigning downstream product identity.

Typical Applications

• Chiral quinuclidine carboxamides: Used as the amino component in coupling with activated carboxylic acids, introducing the rigid S-configured quinuclidinyl fragment into amide-containing molecules.
• Urea-linked bicyclic analogues: Used after salt neutralization in carbonyl-coupling sequences that connect the primary amine through a urea linkage while retaining the basic bridgehead nitrogen.

Specifications

Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.