4-(Piperidin-3-yl)aniline dihydrochloride

4-(Piperidin-3-yl)aniline dihydrochloride is a bifunctional aromatic–alicyclic amine used in niraparib-related synthesis. The aniline group provides a route into aryl-nitrogen bond construction or conversion to other aromatic nitrogen functionality. The piperidine nitrogen supplies a separate site for protection and later release, allowing the two nitrogen centers to be addressed independently.

This dihydrochloride is used as a stereochemically unresolved starting fragment. Its para-substituted phenyl–piperidine framework is already assembled, so downstream operations can concentrate on aromatic elaboration and stereochemical control. Protection of the more nucleophilic piperidine nitrogen separates its chemistry from that of the aniline. This places the material upstream of the completed indazole carboxamide structure.

Typical Applications

• Niraparib aromatic-fragment preparation: Used as an aniline-containing precursor in routes that build the nitrogen-linked aromatic portion of niraparib, carrying the phenyl–piperidine connection into later intermediates.
• Protected piperidinylaniline derivatives: Used to prepare selectively protected derivatives for staged nitrogen functionalization, leaving the aniline available for transformation while temporarily masking the piperidine nitrogen.

Specifications

Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.