4-[4-Fluoro-3-(piperazine-1-carbonyl)benzyl]phthalazin-1(2H)-one

4-[4-Fluoro-3-(piperazine-1-carbonyl)benzyl]phthalazin-1(2H)-one is a late-stage olaparib intermediate with one piperazine nitrogen already attached to the aromatic acid fragment. The remaining piperazine NH provides a selective acylation site, while the benzyl-linked phthalazinone and fluorobenzoyl portions transfer the assembled molecular framework into the final step.

The material is the deprotected piperazine intermediate, positioned after removal of a temporary nitrogen-protecting group. Introducing a cyclopropanecarbonyl group at the available NH completes the olaparib acyl pattern. Other acyl reagents can modify the same site in analogue synthesis, making this intermediate a defined branch point for changing the terminal amide without rebuilding the phthalazinone scaffold.

Typical Applications

• Final olaparib acylation: Used as the free-piperazine substrate in reaction with a cyclopropanecarbonyl reagent, installing the terminal amide on the previously unacylated nitrogen.
• Terminal-amide analogue synthesis: Used with alternative acyl donors to prepare related piperazine diamides, varying the terminal acyl fragment while retaining the phthalazinone–fluorobenzoyl framework.

Specifications

Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.