2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride

2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride is a fluorinated glycinamide building block with a free amino terminus in salt form. The amino group provides a site for acylation or nitrogen substitution, while the existing trifluoroethyl amide transfers a defined fluorinated tail. This allows a glycinamide linkage to be introduced without rebuilding its terminal amide.

The selected hydrochloride is neutralized when the primary amine is needed for coupling. Its amino and amide nitrogens have different reactivities, supporting selective modification at the amino end while retaining the N-trifluoroethyl group. The short glycine-derived spacer connects those functions directly, making the compound useful for peptide-like and heterocycle-containing intermediates that require this specific fluorinated amide pattern.

Typical Applications

• Fluorinated peptide-like amides: Used as the amino component in coupling with carboxylic-acid fragments, introducing a glycinamide spacer terminated by an N-trifluoroethyl group.
• Substituted aminoacetamide intermediates: Used in nitrogen-alkylation or heteroaryl-substitution sequences at the primary amino group, attaching the fluorinated glycinamide fragment to a larger molecular scaffold.

Specifications

Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.