5-Bromo-4-fluoro-1-methyl-1H-indazole

5-Bromo-4-fluoro-1-methylindazole is a halogenated fused heterocycle used as an aryl-coupling fragment. The aromatic bromine provides the attachment site for carbon–nitrogen or carbon–carbon bond formation, while the N-methyl group fixes the nitrogen substitution pattern. The adjacent fluorine is retained in the resulting indazole-containing molecular fragment.

The selected compound is already methylated at indazole N1, leaving the brominated aromatic position as the principal assembly handle. This separates ring-nitrogen substitution from subsequent fragment coupling. In orforglipron-related synthesis, the indazole portion can be connected to a complementary nitrogen-containing heterocycle. The specific bromine position determines the connection point and differentiates this material from other bromo-fluoroindazole isomers.

Typical Applications

• Orforglipron indazole-fragment coupling: Used as the brominated aromatic partner in routes that connect the 4-fluoro-1-methylindazole fragment to the nitrogen-containing imidazolone portion of an advanced intermediate.
• Substituted indazole derivatives: Used in catalytic coupling with suitable carbon or nitrogen partners to vary the C5 substituent while preserving the fluorine and N-methyl pattern.

Specifications

Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.