4-(4-Chlorothiophen-2-yl)thiazol-2-amine

4-(4-Chlorothiophen-2-yl)thiazol-2-amine is a linked thiophene–thiazole building block associated with avatrombopag chemistry. The exocyclic amino group provides a site for connection to an activated heteroaromatic fragment, while the preassembled sulfur-containing rings transfer the chlorothienyl substitution pattern into the downstream structure. The chlorine remains part of the aromatic fragment.

The selected material is the amino-thiazole intermediate, not the completed active ingredient. Its primary synthetic role is to supply a defined heteroarylamino fragment without constructing both sulfur-containing rings during final assembly. Because the amino group is attached to the thiazole ring, its reactivity differs from that of a simple alkylamine. Its identity is also relevant to analytical tracking of avatrombopag-related process material.

Typical Applications

• Avatrombopag heteroaryl-fragment synthesis: Used as the amino-thiazole component in routes that connect the chlorothienyl–thiazole fragment to the complementary molecular portion through nitrogen functionalization.
• Process-related compound analysis: Used as an identified intermediate comparator when developing chromatographic separation of avatrombopag-related material from residual amino-thiazole starting fragments.

Specifications

Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.