4,5,6,7-Tetrahydrobenzothiazole-2,6-diamine

4,5,6,7-Tetrahydrobenzothiazole-2,6-diamine is a racemic aminobenzothiazole intermediate with amino groups on the heterocyclic ring and the saturated ring. The 6-amino group provides a site for side-chain construction and formation of resolving salts, while the 2-amino function is retained in downstream aminobenzothiazole structures. The starting material contains both configurations at the ring stereocenter.

The selected identity is the free base associated with CAS 104617-49-4. It is used before isolation of a specified enantiomer or for synthesis of racemic derivatives. Resolution separates stereochemical selection from subsequent nitrogen functionalization, whereas derivatization of the unresolved material gives a racemic product series. This places the compound earlier in chiral pramipexole- or dexpramipexole-related routes than the individually specified S and R diamines.

Typical Applications

• Chiral diamine resolution: Used as the racemic starting material in resolution processes that isolate an S- or R-configured tetrahydrobenzothiazole diamine for subsequent synthesis.
• Racemic aminobenzothiazole derivatives: Used in nitrogen-functionalization sequences to prepare unresolved N-alkyl or N-acyl compounds for synthetic-route development and comparison with enantiomerically specified materials.

Specifications

Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.