(6R)-6-(2-Amino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol

(6R)-6-(2-Amino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol is a chiral advanced intermediate used in elacestrant-oriented synthesis. It supplies the R-configured tetralin framework and an aniline nitrogen for side-chain construction. The phenolic hydroxyl and aromatic methoxy group carry the required oxygen substitution pattern into downstream derivatives.

Unlike the unresolved scaffold, this material has a specified absolute configuration at the tetralin center. Subsequent nitrogen functionalization can therefore focus on installing the ethyl and benzyl-linked groups without resolving the finished molecule’s core at that stage. The aniline and phenol have different chemical roles, allowing side-chain attachment to be separated from any temporary protection or restoration of the phenolic oxygen.

Typical Applications

• Elacestrant nitrogen-side-chain installation: Used as the chiral amine-containing core in routes that introduce the ethyl and substituted benzyl groups required on the aniline nitrogen.
• Chiral aminotetralin analogue synthesis: Used with alternative alkylating or carbonyl partners to prepare related N-substituted compounds while retaining the defined R-configured phenolic tetralin framework.

Specifications

Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.