Imidazole-4,5-dicarboxylic acid
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Chemical Product Description & Applications
Imidazole-4,5-dicarboxylic acid combines an imidazole ring with two adjacent carboxylic acid groups. It functions as a heterocyclic synthesis building block and as a nitrogen/oxygen-donor ligand precursor for coordination materials. The carboxyl groups provide sites for esterification or amide formation, while the imidazole ring contributes a distinct nitrogen-containing framework.
The selected free acid is different from an alkali-metal imidazoledicarboxylate or an isolated metal complex. Its multiple acidic and coordinating sites permit different degrees of deprotonation and different linking arrangements in metal-containing structures. In organic synthesis, the same adjacent acid groups offer access to functionalized imidazole derivatives, making the material relevant to both molecular construction and extended coordination-network development.
Typical Applications
- Coordination polymers and MOF research: Used as an organic linker precursor with metal ions, where carboxylate oxygen and imidazole nitrogen sites support assembly of metal-linked structures with different coordination geometries.
- Imidazole ester and amide synthesis: Used as a dicarboxylic-acid starting material for preparing functionalized imidazole derivatives. Conversion of the acid groups introduces substituents while retaining the nitrogen heterocycle.
Specifications
| Parameter | Specification | Test Method |
|---|---|---|
| Appearance | Solid; color consistent with the reference sample | Visual inspection |
| Identification | Consistent with authenticated reference | FTIR fingerprint comparison |
| Chromatographic purity | ≥98.0 area% | HPLC with suitable UV or CAD detection |
| Total organic impurities | ≤2.0 area% | HPLC, area normalization |
| Largest individual impurity | ≤1.0 area% | HPLC, area normalization |
| Water | ≤1.0% w/w | Karl Fischer titration |
Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.
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