(S)-1-(4-Methoxyphenyl)ethylamine

(S)-1-(4-Methoxyphenyl)ethylamine is a chiral primary amine used as a resolving reagent and as a stereodefined building block or auxiliary. Its amine forms salts with carboxylic acids and can be incorporated into imines or amides, while the established stereocenter introduces a defined chiral environment into the resulting intermediates.

The selected product is the S-configured free amine rather than its R enantiomer, racemate or an isolated salt. The para-methoxyphenyl group distinguishes its chemical behavior and downstream removal options from those of unsubstituted alpha-methylbenzylamine. This combination of a reactive primary amine and an existing stereocenter supports both separation-based resolution and synthesis in which chirality is introduced through a temporary or retained nitrogen substituent.

Typical Applications

• Diastereomeric salt resolution: Used with suitable racemic carboxylic acids to form diastereomeric ammonium salts, allowing differences in crystallization behavior to separate the acid enantiomers.
• Chiral imine and amide intermediates: Used to prepare nitrogen-containing derivatives in asymmetric synthesis, where the S-configured amine provides a stereochemical element during subsequent transformations.
• Complex natural-product synthesis: Used as a precursor to chiral intermediates in reported solanoeclepin A synthesis, contributing an amine-derived stereochemical component within a multistep construction sequence.

Specifications

Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.