6-(2-Amino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol

6-(2-Amino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol is an advanced aminophenyl–tetralin intermediate associated with elacestrant synthesis. Its aniline provides the site for installation of the nitrogen-linked side chain, while the phenolic hydroxyl supplies the oxygen functionality retained in the target framework. The aromatic and tetralin fragments are already joined.

The selected entry has no single absolute configuration assigned, so it belongs before completion of the route’s stereochemical selection. Its free aniline permits staged nitrogen functionalization, while the phenol can be retained or temporarily protected as required by the sequence. Resolving or otherwise controlling the tetralin stereocenter separates molecular assembly from preparation of the specific configuration used in downstream elacestrant chemistry.

Typical Applications

• Chiral elacestrant-core preparation: Used as an unresolved advanced scaffold in routes that isolate the required tetralin configuration before final nitrogen-side-chain assembly.
• N-Substituted aminotetralin derivatives: Used in alkylation or reductive-amination sequences at the aniline, attaching side-chain fragments to the preassembled phenolic tetralin core.

Specifications

Specifications describe the standard grade. Tolerance, test method and documentation package are confirmed per order.